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TICs maintain lower intracellular ROS levels than other cancer cells within the tumor, primarily through the accumulation of ROS scavengers like glutathione and the overexpression of Gclm and glutathione synthetase, the enzymes necessary for its synthesis, as shown in breast and liver cancer stem cells [18, 20]

The treatment of PDAC requires novel targets and increasing interest in research regarding novel cancer biomarkers has been focused on the GST family which contributes to the malignant phenotype of many cancers

Speaking or singing for extended periods, yelling or straining your voice can all cause your vocal cords to become irritated and inflamed, eventually causing lesions

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