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additional non-oral contraception is recommended during initiation and after dose increases Pregnancy and breastfeeding : Tirzepatide is not recommended during pregnancy or breastfeeding as per MHRA guidance Lifestyle modifications : Alcohol moderation, healthy dietary patterns, and regular physical activity Healthcare professionals should maintain vigilance for pancreatitis throughout treatment duration, recognising that whilst this remains a rare complication, early detection significantly improves outcomes

Patients should be counseled that evidence for low-dose regimens specifically for inflammation is limited, and alternative evidence-based anti-inflammatory strategies (lifestyle modification, statins, specific anti-inflammatory medications for diagnosed conditions) should be prioritized