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Future Directions and Research Priorities Emerging Therapeutic Approaches Triple agonist retatrutide and combinations including cagrisema have progressed to phase 3 trials as obesity treatments with early data suggesting even greater weight loss than tirzepatide [83]

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The Specialist Pharmacy Service (SPS) advises that if a patient is already taking a DPP-4 inhibitor and requires treatment intensification, switching to a GLP-1 receptor agonist (rather than adding it) is the preferred approach

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