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Mollan, M.Bc.H.B., a neuro-ophthalmologist at University Hospitals Birmingham, floated the notion that the rapid normalization of the cardiometabolic system semaglutide might be the cause of the NAION side effect rather than semaglutide itself

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Over time, this can reduce thyroid hormone production, leading to hypothyroidism and symptoms such as weight gain, fatigue, sensitivity to cold and a slower metabolism