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The carcinogenic risk of GLP-1RAs remains controversial: large-scale cohort studies have not identified an association with pancreatic cancer 36 , but animal experiments suggest that long-term high-dose use may induce ductal hyperplasia 37,38
Adults who are overweight and have weight-related health conditions
Patients should be advised to seek prompt medical evaluation for severe or persistent gastrointestinal symptoms, vision changes, unusual neck swelling or hoarseness, or severe constipation with abdominal distention
However, it is considered an important risk factor for weight gain ( Figure 1 )
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