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C.GollowitzerA.LaoukiliJ.KranenburgO.WerzO.KoeberleA.et al (2020)
This article reconstructs that timeline from published, peer-reviewed sources and public regulatory records, and confines itself to what those sources report
Metformin can also exert its glucose-lowering effects through a gut-liver-brain axis ( 3 Adverse effects 3.1 Gastrointestinal effects Despite its widespread availability and affordability, metformin is associated with gastrointestinal side effects, including nausea, vomiting, diarrhea, and bloating, affecting around 20% of patients (Sanchez-Rangel and Inzucchi, 2017
Both bypass the gut, so both produce strong serum levels
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