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The physiological principles that regulate the glomerular filtration, tubular secretion, luminal tubular uptake and re-elimination of nanoparticles in the kidneys may facilitate the selective targeting of nanoparticles to specific segments of the nephron

Patients with Type 2 diabetes have many other drug treatment options, including other GLP-1 receptor agonists like Mounjaro (tirzepatide) and Trulicity (dulaglitude)

Furthermore, the TG levels (65.15%) were also decreased (Supplementary Fig

Besides, in H9c2 cardiomyocytes, GLP-1RAs also inhibit hypoxia-induced NLRP3 inflammasome activity and TNF- to attenuate pyroptosis through modulating the SIRT1/NADPH oxidase 4 (NOX4)/ROS pathway [139]