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The animals develop seizures, and the authors suggested that the extracellular brain glutamate concentration had become increased, perhaps due to excessive release of glutamate and/or decreased extracellular clearance
Neutralizes and intercepts toxins in the GI tracts before they are even absorbed
Oral BPC-157 bioavailability is overstated
The 20-30 hour half-life means the peptide still distributes systemically regardless of site, so any local-only effect is partial at best
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