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Seek urgent medical attention (contact 999 or attend A&E) if you experience: Signs of severe dehydration : extreme thirst, very dark urine, dizziness, confusion, or reduced urine output Heat exhaustion or heat stroke : high body temperature (above 40C), rapid pulse, headache, nausea, or altered consciousness [15] Severe abdominal pain , particularly if accompanied by persistent vomiting, which could indicate pancreatitis (a rare but serious side effect of GLP-1 agonists) [1] [8] Allergic reactions : difficulty breathing, swelling of face or throat, or widespread rash Contact your GP or diabetes care team within 2448 hours if you notice: Persistent heat intolerance that significantly affects daily activities or quality of life Ongoing gastrointestinal symptoms lasting more than a few days, which may require dose adjustment Signs of mild to moderate dehydration that do not improve with increased fluid intake New or worsening symptoms that concern you, even if they seem unrelated to temperature If you cannot contact your GP and need urgent but non-emergency advice, call NHS 111
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In autoimmune diseases such as systemic lupus erythematosus (SLE), mitochondrial damage and the release of mitochondrial DNA (mtDNA) into the cytoplasm and extracellular space have been observed [130]
The mean estimated ALSFRS-R total score was 42.8 at baseline, 30.6 at month 12 and 18.4 at month 24 in treated subjects, with a mean slope of 1.0, as compared to 41.9, 25.4 and 8.8 in not treated subjects, with a mean slope of 1.4 (slope difference: 0.4
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