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Between 25 and 30, most people start to notice fine lines across their forehead, between their brows (frown lines or 11s in the glabella), on the outside corners of their eyes (crows feet), or around their mouth (smile lines or nasolabial folds)
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Specifically, beyond the enteroendocrine L-cells of the intestine, GLP-1 is also produced as a neuropeptide by the pre-proglucagon neurons in the brain stem 3
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