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Oct 2015;102(4):943-50

Retatrutide is a triple hormone receptor agonist, acting on three receptors simultaneously: GLP-1 (glucagon-like peptide-1) reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) enhances insulin secretion and may improve fat metabolism Glucagon receptor increases energy expenditure and promotes fat breakdown It is worth noting that glucagon receptor agonism can, in isolation, raise blood glucose levels

Even on days when the side effects hit hard and I feel like just staying put, I try to stay active

Weeks 21 and beyond: maximum dose of 15mg The 15mg dose is the maximum approved weekly dose of tirzepatide