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Because GLP-1 medications slow digestion, introducing high-dose THC may intensify gastrointestinal effects in sensitive individuals
The GIP receptor component is believed to enhance metabolic and weight-loss effects, whilst glucagon receptor activation is hypothesised to increase energy expenditure and promote hepatic fat breakdown (lipolysis)
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An individual participant data meta-analysis of 23 large randomised trials (covering over 150,000 people) found that during the first year of statin therapy, the absolute excess of muscle pain or weakness was about 11 cases per 1,000 people per year
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