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While hypothermia provides significant neuroprotection, its proposed mechanisms are multifactorial and may include modulation of neurotransmitter systems and potentially influencing metabolic pathways involving compounds like carnitine (56)

doi: 10.7861/clinmedicine.19-2-129

Arthritis Care Res (Hoboken), 2010

These metabolic signatures can separate MoA classes across a compound series, prioritise hits from phenotypic screens, and generate mechanistic hypotheses for subsequent validation by metabolic pathway drug response profiling or orthogonal proteomics approaches

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