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Results Body weight, fat mass, and cecal mass As expected, obese mice (maintained on an HFD followed by WD) had significantly higher body weights than mice continuously maintained on LD

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A subset of cultured cells expressed GLP- 1 receptor, and mice with a-cell specific GLP- 1 receptor knockout have mild glucose intolerance and higher glucagon secretion in response to glucose challenges than animals of the wild type, which may indicate that GLP- 1 directly affects this cell [69]