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J Clin Endocrinol Metab (2021) 106:301933
A reasonable hypothesis is that the rapid cycling allows the liver to respond quickly to the glutathione requirements of other tissues
Lastly, despite PDE5i treatment has been proven a cost-effective therapeutic strategy, compared to no treatment [62], the relatively high cost of a chronic treatment with some reference/equivalent pharmaceutical formulations belonging to this category of drugs might still represent a limitation for patients with economic constraints, by contributing to treatment discontinuation
Their results demonstrate that GLP-1, through an unknown mechanism, can preserve axonal and neurofilament structure despite the induction of progressive neurotoxicity, thus illustrating neuroprotective properties that can be leveraged against disorders in the central nervous system [60]
