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Pachyonychia congenita (Jadassohn-Lewandowsky syndrome),125,152 another autosomal dominant genetic disorder, 151,152 is characterized by hypertrophy of the nail plate, with severe thickening and yellowish-brown discoloration of the nail plate (Fig
Nevertheless, factors such as supply challenges, restricted funding, high out-of-pocket costs and side effect fears could limit the uptake of the drugs, creating uncertainties around the future size and shape of demand
These associations are shown in red above, with increased risk reflected in hazard ratios greater than one
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