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Although obestatin has clear demonstrated activity as an anorectic hormone, inducing decreased food intake, reduced body weight gain, as well as being involved in the regulation of sleep patterns and cell proliferation, no definitive receptor for this hormone has been identified

A 2021 review in Frontiers in Pharmacology organised the wound-healing literature by tissue category, covering dermal, tendon, ligament, skeletal-muscle, osseous, peripheral-nerve, and vascular models (PMID 34267654)

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Ultimately, available evidence suggests that the long-term safety profile of GLP-1 receptor agonists remains favorable for most patients who tolerate therapy during the early stages of treatment