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Metallothioneins (MTs), small cysteine-rich proteins, act as zinc-binding proteins to buffer and store zinc ions, protecting cells from oxidative stress and regulating zinc availability [48]
The level of GSH/GSSG in the cells treated with NS for more than 6 h was also significantly decreased, but the extent was smaller than that in the NSBSO group, indicating that the combination of consumption of existing GSH and inhibition of GSH synthesis promotes the exhaustion of GSH in cells
Feeding behavior is itself under circadian control, with appetite, digestion, and metabolic hormone release peaking at certain times, but reciprocally, the timing of food intake also feeds back onto the clock as a zeitgeber for peripheral organs
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