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Clinicians treating obesity should screen for the presence of eating disorder psychopathology before prescribing GLP-1RAs, as these medications are contraindicated in cases of overweight or obesity associated with atypical anorexia nervosa, bulimia nervosa, and subthreshold bulimia nervosa

When the FDA declared a national shortage of semaglutide, a GLP-1 receptor agonist, in March 2022, compounding pharmacies gained legal permission to produce custom versions of Novo Nordisks key ingredient in Ozempic and Wegovy

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But regulatory approvals are never guaranteed, and unexpected safety signals can delay or derail the process