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Moreover, GLP-1RA exendin-4 improves insulin resistance by directly inhibiting the activation of nuclear factor-kappa-B (NF-B) within the murine macrophage cell line RAW264.7 [88, 89]

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In lipopolysaccharide (LPS)-induced intestinal injury mouse models, the intestine rapidly responds to ischemic damage, characterized by increased GLP-1 secretion following intestinal barrier injury (56)

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