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Current clinical practice favors once-daily dosing regimens [11, 12], which optimize therapeutic efficacy while attempting to mitigate the characteristic nephro- and ototoxicity associated with this drug class [13, 14]
Fujioka K, ONeil PM, Davies M, Greenway F, C.W
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Dehydration, inadequate protein intake, sleep deprivation, and underlying thyroid or electrolyte disorders can all cause or worsen fatigue
