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doi: 10.1016/j.jhep.2021.03.014 59

Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons

Designing small molecules able to target multiple receptors might sound difficult, but Septerna says the allosteric binding site it has discovered is even better conserved across all incretin receptors than the site targeted by peptides and other small molecule drugs

The cultures were cooled on ice before the addition of 0.1 mM isopropyl--d-thiogalactopyranoside (GoldBio) to induce protein expression

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