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Funding This work was supported by the National Key R&D Program of China (grant number: 2023YFC3404100, 2023YFC2506400), and National Natural Science Foundation of China (grant number: 82325042, 82203860), and Shanghai Municipal Education Commission Scientific Research Innovation Project (grant number: 2023-05-50), Wu Jieping Medical Foundation Research Project (grant number: 32067502023-18-29)

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*Correspondence: Leif Hertz, RR 2, Box 245, Gilmour, K0L 1W0, Ontario, Canada