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13 This study found that rats treated with exendin-4 had increased endothelial progenitor cells and protein levels of vascular endothelial growth factor receptor-2 (VEGF R2), phosphorylated endothelial nitric oxide synthase (eNOS), matrix metalloproteinase-2 (MMP-2), and transforming growth factor- (TGF-)

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These hormones target the anterior pituitary gland, to make a disruption in its related hormones such as adrenocorticotropic hormone, antidiuretic hormone, follicle-stimulating hormone, growth hormone, luteinizing hormone, oxytocin, prolactin, and thyroid-stimulating hormone (82, 83)