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In this sense, studies based on real-world clinical information like the VID are at risk of well-known biases such as differential recording, misclassification bias or missing data

For instance, studies combining metagenomics, metatranscriptomics, and metabolomics in prodromal and established PD have identified early functional alterations in microbial activity, including changes in metabolites such as isovalerate and valerate, and shifts in pathways related to glutamate metabolism, chemotaxis, and flagellar assembly [19]

Characterised in the literature for its high affinity for Cu(II) and its effects in cultured fibroblast models

In patients with pre-existing seizure activity, an increase in seizure frequency and/or severity has been reported