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Johannes CB, Ziemiecki R, Pladevall-Vila M, et al
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indicated that empagliflozin partially exerted anti-oxidative stress and anti-apoptotic effects on cardiomyocytes under high glucose conditions by activating AMPK/PGC-1 and suppressing other RhoA/ Rho-associated protein kinase (ROCK) pathway in diabetes-induced cardiomyopathy mice [107]
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