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Dosing is often titrated based on clinical response and tolerability rather than being strictly weight-based, and the clearance time remains relatively consistent across different individuals
The avermectins selectivity is due to the fact that some mammals do not have glutamate-gated chloride channels and that the avermectins have a low affinity for mammalian ligand-gated chloride channels
10.1016/j.peptides.2015.02.007 68
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