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258 Moreover, the ectopic expression of mutant SOD1 (G86R) promoted p53 phosphorylation and increased p53 levels in PC12 cells
Infection by SARS-CoV-2 or other viruses has been shown to substantially increase production of free radicals by the immune cells leading to oxidative stress
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This dual activation cascade induces catastrophic breakdown of alveolar-capillary barrier integrity, manifesting pathologically as alveolar edema, neutrophilic inflammation, and refractory hypoxemia (Cheng et al., 2017
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