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Because glutathione plays an important role in cellular protection, lower levels are often discussed in relation to healthy ageing and vitality
Specifically, in cells, lysine is sequentially catalyzed by enzymes including AASS, ALDH7A1, AADA, DHTKD1 to generate glutaryl-CoA, which is then catalyzed by crotonyl-CoA-producing enzyme glutaryl-CoA dehydrogenase (GCDH) to produce crotonyl-CoA, that is, the precursor for the crotonylation of histones and non-histone proteins [37]
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