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It is important to note that organelle-containing erythroid lineage cells can undergo intrinsic [37] and extrinsic apoptosis [38], receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-dependent necroptosis [39], or iron-driven ferroptosis [40]

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The glutathione molecule is composed of three amino acids: glutamate, glycine, and cysteine

Variants that reduce CYP activity can slow initial metabolism, but if phase II is also impaired, reactive metabolites can still accumulate and damage DNA, mitochondria, and tissues like the liver and kidneys