Reduced caloric intake is perhaps the most significant contributor
CAFs upon activation secretes growth factors, cytokines, and ECM molecules including TGF-, matrix metalloproteinases (MMPs), hepatocyte growth factor (HGF), and fibroblast growth factors (FGFs), which are implicated in tumor development, invasion, and metastasis (120)
While this can lead to faster fading of dark spots , it also comes with higher risks: Skin irritation and redness Burning or stinging sensation Increased sun sensitivity Risk of rebound hyperpigmentation Potential long-term complications if misused This is why dermatologists strictly control how long and how often hydroquinone should be used
If you have a history of gastritis, ulcers, or other stomach conditions, the combination of GLP-1 medications and alcohol may be particularly problematic