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The dose can be increased to 3.0 mg if needed after at least 4 weeks on the 1.5-mg dose and increased again to 4.5 mg if needed after at least 4 weeks on the 3.0-mg dose
J Drug Metab Toxicol 2:16
What we like about a two product, targeted approach is that it attempts to address both directions of the GLP-1 pathway: Direct activation of L cells and receptor signalling Indirect support through the gut microbiome and metabolic environment That means we are not just telling the body to release more GLP-1, but also creating the conditions for GLP-1 to be more effective and longer lasting
In addition, it has been reported that the pro-inflammatory factor IL-1 induces ER stress-related apoptosis in cultured chondrocytes 14
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