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However, an important shift is occurring in clinical practice: we are recognizing patients with socalled lean MASLD and questioning whether our traditional therapeutic frameworks adequately address the full spectrum of disease

Access this article Similar content being viewed by others Abbreviations -GCL: -glutamate cysteine ligase GGT: -glutamyl transferase BSO: L-buthionine-(S, R)-sulfoximine GPx: glutathione peroxidase GSH and GSSG: reduced and oxidized glutathione, respectively MAPK: mitogen-activated protein kinase miR: microRNA Nrf2: NF-E2-related factor 2 ROS: reactive oxygen species REFERENCES Scir, A., Cianfruglia, L., Minnelli, C., Bartolini, D., Torquato, P., Principato, G., Galli, F., and Armeni, T

In some ways, glutathione can be said to have dual antioxidant action

This perspective serves as a call to action for research and clinical innovation to address the psychosocial effects of GLP-1s on adolescents