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However, due to the paucity of data, observed differences in efficacy cannot be generalized to patients affected by overweight (that is, with BMI 2730 kg m 2 ) or to those with a BMI 40 kg m 2
But large-scale human clinical trials are still needed
Moreover, the influence of physicochemical properties on the in vitro and in vivo release profiles, weight loss, diabetic control, and long - term stability of the product were investigated
According to the invention, an ionic liquid Linker is introduced on a conventional solid phase carrier, and then the Linker is sequentially connected with corresponding amino acids in a semaglutide sequence through a solid phase synthesis method, and the semaglutide protamine is obtained through cracking and purification
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