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1 Introduction Until recently, the worldwide increase in obesity, characterized by a body mass index (BMI) exceeding 30 kg/m 2 , was widely considered an inevitable trend with limited hope for meaningful advances in pharmacological treatment

It's most commonly treated by wearing a CPAP machine to bed

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[55] This specificity reflects the distinct metabolic roles of the respective coenzymes, and is the result of distinct sets of amino acid residues in the two types of coenzyme-binding pocket