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The duration of 7 weeks was chosen based on a prior human study in CFS patients showing that the greatest improvement against fatigue took place between 4 and 8 weeks (30) and rodent studies showing effects on brain serotonin levels already after 21 25 days of carnitine supplementation (32, 33)

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Beyond weight loss: the disease-modifying potential of GLP-1s Mike Haney: So mechanistically it sounds like the outcome is the same as what we would be trying to achieve with lifestyle which is essentially negative energy balance

The slowing of gastric emptying, whilst beneficial for blood sugar control and satiety, can initially cause the digestive system to adjust, leading to nausea and related symptoms