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It is found in many species including bacteria, yeast, mammals, and plants

CHAC1 further exacerbates cellular stress by degrading GSH, intensifying oxidative damage and ultimately driving ferroptotic cell death (Figure 5) ( FIGURE 5 While the eIF2K3/PERK-eIF2-ATF4 cascade, another branch of the ISR, can modulate ferroptosis in the context of ER stress, cysteine deprivation selectively activates GCN2 rather than PERK, highlighting distinct regulatory mechanisms ( Cysteine starvation triggers mitochondrial fragmentation, impairs mitochondrial function and leads to the accumulation of ROS ( CHAC1 is upregulated through the ATF4-dependent ISR pathway, where it degrades GSH to liberate cysteine needed for the synthesis of Fe-S cluster proteins (Ward et al., 2024)

Epithalon product information: Molecular Formula: C14H22N4O9 Sequence: H-Ala-Glu-Asp-Gly-OH Molecular Weight: 390.349 g/mol View the HPLC Certificate here

The protein produced under ISO 9001:2015 conditions contains 83 amino acids and an N-terminal 14 amino acid histidine tag for atotal length of 97 amino acids and has a predicted molecular mass of 10.8 kDa