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Concurrently, the focal adhesion pathway was hyperactivated, as evidenced by the upregulated expression of key adhesion and cytoskeletal linker proteins, including Actn1 , Tln1 , and Rac2 (3.1- to 8.5-fold), suggesting enhanced cell-ECM adhesion signaling under HFD

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More serious deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes