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4 However, they showed that DNA sequencing alone cannot predict PRC2 functional status in all malignant peripheral nerve sheath tumors and that the positive and negative immunostaining for H3K27me3 is highly concordant with the PRC2 wild-type (no mutation) and the homozygous loss of genetic status, respectively

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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress