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Many participants in the trials achieved excellent results at 8 mg without needing to escalate to the 12 mg maximum, which suggests that the highest dose is not necessary or appropriate for everyone

Initial Increased Cortisol, Followed by Depleted Steroids Chronic stress and blood sugar imbalances both lead the body to produce high levels of the stress hormone cortisol, which may result in us feeling wired but tired, and trigger adrenal fatigue

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UPR activation is particularly prominent in active MS lesions, driven by increased levels of inflammatory cytokines, reactive nitrogen species (RNS), and ROS