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Who Should Not Take Semaglutide Semaglutide should not be used in individuals who: Have type 1 diabetes Have diabetic ketoacidosis Have a personal or family history of medullary thyroid carcinoma Have MEN 2 Have known hypersensitivity to semaglutide Patients with severe gastrointestinal disease should discuss risks carefully with their specialist

Poor sleep can increase hunger signals and reduce motivation

It is the maximum FDA-approved maintenance dose of tirzepatide, and the one that produced the most dramatic results in clinical trials

Nooverlapping tirzepatide and semaglutide can cause excessive receptor stimulation and severe side effects