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The current evidence is mainly derived from analyses of circulating and urinary biomarkers, as well as small-scale observational studies
They also affect signals in the brain linked to feelings of fullness and satisfaction, tamping down appetite, food-related thoughts and cravings
Target range is typically the upper quartile of the normal range for your age
In the landmark STEP 1 trial, adults with obesity lost an average of 14.9% of their body weight over 68 weeks, versus 2.4% on placebo (New England Journal of Medicine, 2021)
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