Further research in this area is of merit, to determine the impact and requirements for B vitamins and other nutrients that support methylation in individuals with this specific genetic polymorphism (Cirilo et al., 2021)
Possible side effects of B12 + MIC shots include: Injection site reactions Mild pain, redness, or swelling at the injection site
Biochem Biophys Res Commun 417:4348 Shukla D, Mandal PK, Tripathi M, Vishwakarma G, Mishra R, Sandal K (2020) Quantitation of in vivo brain glutathione conformers in cingulate cortex among age-matched control, MCI, and AD patients using MEGA-PRESS
Based on available research and anecdotal reports: Week 1 to 2: Initial reduction in inflammation and pain may be noticed Some users report improved mobility at injury sites Gastrointestinal benefits may become apparent for those using oral forms Week 2 to 4: More noticeable improvements in tissue healing Continued reduction in inflammation Enhanced range of motion and functional recovery Week 4 to 8: Significant structural improvements in healing tissues Continued functional gains Many users report substantial recovery milestones The peptide has a relatively short half-life of less than 30 minutes, following linear pharmacokinetics after administration