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Tirzepatide causes diarrhea at higher rates than semaglutide (2535% vs 1822%) due to its GIP receptor agonism, but the absolute difference is modest and symptom duration is similar between the two medications
KEY TAKEAWAY: If you can survive weeks 6-8, youll likely succeed long-term
Allow refrigerated pens to reach room temperature (15-30 minutes) before injection to improve comfort and reduce injection site reactions
Always consult the FDA-approved prescribing information for your specific GLP-1 medication, as storage requirements vary between products
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