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It has been possible to map the incretin function in humans in some detail owing to the availability of receptor antagonists for both hormones, namely exendin 9-39 for the GLP-1 receptor and the amidated GIP fragment GIP 3-30 amide for the GIP receptor [2]

It is not licensed by the MHRA, is not available on NHS prescription, and has not been appraised by NICE for any indication

8 The following algorithm has been proposed for the management of patients taking GLP-1-RA presenting for surgery (Figure 2)