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Abbreviations AHI: Apnea-Hypopnea Index CV: Cardiovascular ETD: Estimated Treatment Difference HFpEF: Heart Failure with Preserved Ejection Fraction MACE: Major Adverse Cardiovascular Events MASLD: Metabolic-Associated Steatotic Liver Disease MASH: Metabolic-Associated Steatohepatitis OA: Osteoarthritis QOL: Quality of Life RRR: Relative Risk Reduction (1-Hazard Ratio) References Apovian CM

It has been illustrated that VPA is approved by the U.S

These include: Biotin deficiency Vitamin B2 (Riboflavin) deficiency Essential fatty acid deficiency A deficiency in biotin can show similar skin symptoms and can also lead to muscle weakness, lack of coordination, seizures, and hearing loss

Most patients experience significant weight loss within the first 6-12 months of using GLP-1 medications