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In the 60s, patients in the UK received one injection a month

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Shaking creates foam and mechanical stress that breaks peptide chains

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Provine NM, Amini A, Garner LC, Spencer AJ, Dold C, Hutchings C, et al

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In 2012, the New England Compounding Center in Framingham, Massachusetts, created a run of injectable steroids for patients across the US

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