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Both human and animal studies have demonstrated that GLP-1 contributes to the physiological control of appetite and meal size (108, 181186)
There are some concerns around use of the GLP-1 agents, such as weight regain after stopping treatment, the potential for a loss of skeletal muscle mass, long-term adherence, and the limited evidence that exists for long-term safety, Moiz et al say
It can distinguish the original form of drugs from complex metabolites, and there is no need to prepare additional antibodies or radioisotope-labeled compounds
Because of this, Ozempic carries a boxed warning from the FDA
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