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Using the Broad Institute's Connectivity Map (CMap), which compares gene expression signatures across thousands of compounds, Pickart et al

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Its primary job is to signal your brain that youre full, regulate blood sugar by stimulating insulin release, and slow gastric emptying so food stays in your stomach longer

Histological analysis After the short-term MIA study, mice were euthanized on day 11, and the entire knee joints were removed and fixed in 4% PFA at 4C for 72 h and then decalcified with 14% EDTA solution (pH 7.4)