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Though the drug is a diuretic agent that can assist horses in excreting up to 20 to 30 pounds in urine on race day and may have some impact on total circulating blood volume, it likely has an effect on the ability of vessels within the lungs to relax and accommodate greater volume expansion as well

On rare occasions when needed, they still created individualized concoctions but the number of prescriptions that required some kind of compounding dropped from 75% in the 1930s to less than 5% by 1960

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